SPDR Series Trust - State Street SPDR S&P Biotech ETF is an exchange traded fund launched by State Street Global Advisors, Inc. The fund is managed by SSGA Funds Management, Inc. It invests in public equity markets of the United States. It invests in stocks of companies operating across health care, pharmaceuticals, biotechnology and life sciences sectors. The fund invests in growth and value stocks of companies across diversified market capitalization. It seeks to track the performance of the S&P Biotechnology Select Industry Index, by using representative sampling technique. SPDR Series Trust - State Street SPDR S&P Biotech ETF was formed on January 31, 2006 and is domiciled in the United States.

Apogee Therapeutics, Inc.

Oruka Therapeutics, Inc.

Dianthus Therapeutics, Inc.

Erasca, Inc.

Twist Bioscience Corporation

Kymera Therapeutics, Inc.

Spyre Therapeutics, Inc.

Revolution Medicines, Inc.

CG Oncology Inc.

Protagonist Therapeutics, Inc.

Healthcare

Financial Services

State Street SPDR S&P Biotech ETF

XBI Holdings & Sector Breakdown