PILL seeks to deliver investment results of 3x the daily performance of the S&P Pharmaceuticals Select Industry Index, a modified equal-weighted index that measures the performance of pharmaceutical companies, as defined by GICS, on the S&P Total Market Index. The fund uses derivatives and swaps to achieve its target exposure. As a levered product with daily resets, PILL is designed as a short-term trading tool and not a long-term investment vehicle. As a result, long-term returns could materially differ from those of the underlying index due to daily compounding. Prior to August 2, 2019, the fund aimed to provide 3x leveraged exposure to the Dynamic Pharmaceutical Intellidex Index. Effective February 27, 2026, the fund replaced the term Shares in its name with ETF.

Crinetics Pharmaceuticals, Inc.

MBX Biosciences, Inc. Common Stock

Atai Beckley Inc.

Definium Therapeutics, Inc.

Enliven Therapeutics, Inc.

Alumis Inc.

Nuvation Bio Inc.

Amylyx Pharmaceuticals, Inc.

Trevi Therapeutics, Inc.

Harrow Health, Inc.

Healthcare

Direxion Daily Pharmaceutical & Medical Bull 3X Shares ETF

PILL Holdings & Sector Breakdown