Nuwellis, Inc. is a medical device firm specializing in the creation, production, and commercialization of devices for ultrafiltration therapy. Its primary offerings, the Aquadex FlexFlow and Aquadex SmartFlow systems, are specifically designed to address fluid overload in patients who have not responded adequately to diuretic medications. The Aquadex FlexFlow system, for instance, consists of a main console, a single-use blood circuit, and a catheter.